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BLOOM'S SYNDROME AND AGING
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The National Institute on Aging defines aging as the biological changes that occur over the course of life. We are born, we mature, we grow old, we die. In Bloom’s syndrome, the question is: Is aging premature? Does aging occur more quickly in persons with Bloom’s syndrome than in other people? Some scientists have said that Bloom’s syndrome is a progeroid syndrome, that is, persons with Bloom’s syndrome age prematurely compared to the average person. Is this true? How can we think about this question?

The most important point to make is that we are aware of no publication, no article, no available information that provides conclusive evidence that persons with Bloom’s syndrome exhibit premature aging. The evidence from the Bloom's Syndrome Registry indicates that persons with Bloom’s syndrome do not exhibit prematurely the features associated with advanced age, such as gray hair, sagging skin, atherosclerosis and its complications, cataracts, and so on. There are, however, four main reasons why the question of premature aging arises in Bloom’s syndrome, specifically…

  1. Persons with Bloom’s syndrome do not live as long as other people.
  2. Persons with Bloom’s syndrome develop cancer and diabetes sooner than the average person, and these diseases are associated with aging.
  3. It has been reported that fibroblast cell lines reach a set point known as replicative senescence more quickly than normal cell lines.
  4. Bloom’s syndrome is aligned scientifically with a syndrome that is widely accepted as progeroid—Werner syndrome—because each syndrome features mutations in a gene that is part of the RecQ helicase gene family; the RecQ helicases are related evolutionarily and have similar biological functions.

Please refer to the following subtopics for more discussion:

Definition of "replicative senescence" from the WWW...

a limitation in the number of times that cells can divide; appears to be a basic feature of somatic cells except for most tumor cells and possibly some stem cells. The cell division's counting mechanism is posited to exist as a consequence of a telomere-shortening hypothesis.

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BSA Blog

2016 Bianco Family's Fundraiser

Second annual fundraiser in memory of Vanessa Bianco and for the benefit of all individuals and families affected by Bloom’s syndrome. All proceeds from the 2016 campaign will go to Bloom’s Syndrome Association in support of its mission.

For more information and to make a donation, please visit the CrowdRise webpage for the 2016 Bianco Family's Fundraiser.

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